in the fight against cancer has just been published. This time, we from the PlasmidFactory are represented with two contributions. We thank the editor Wolfgang Walther for his great work in the new edition of this informative book and the invitation to participate.
Minicircles for CAR T Cell Production by Sleeping Beauty Transposition: A Technological Overview
Minicircle DNA for a CAR transgene in the form of a Sleeping Beauty transposon, and minicircle for SB transposase gene, both produced by PlasmidFactory prove successful in efficiently generating CAR T cells against B-cell malignancies.
Authors: Sabrina Prommersberger, Razieh Monjezi, Ram Shankar, Marco Schmeer, Michael Hudecek, Zoltán Ivics et al.
Capillary Gel Electrophoresis (CGE) for Quality Control of Plasmid DNA in Gene Therapy: Quality Control of 20 Years Stored GMP-Grade Plasmid DNA
Capillary Gel Electrophoresis proves to be a powerful analytical QC tool for measuring the stability of plasmid DNA under long-term storage.
Authors: Marco Schmeer, Martin Schleef, Ram Shankar, Dennis Kobelt, Wolfgang Walther