The better way to DNATM

25 Years as a reliable Partner and experienced CDMO for Plasmids & Minicircles

3,500+ plasmid & Minicircle projects successfully delivered

99.9% success rate

From Research and High Quality to full GMP manufacturing

Proven in multiple clinical trials

Exceptional batch-to-batch consistency and purity

Fast turnaround and scalable production

Worldwide availability with global project support

Trusted CDMO partnership and long-term customer satisfaction

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We understand our clients’ needs – PlasmidFactory is an independent, innovation-driven CDMO combining flexibility, reliability, and efficiency in the production of plasmid DNA and proprietary, exclusive Minicircle technology for research, preclinical, and GMP applications in advanced therapies.

With strong research and development expertise and an exceptionally high success rate across platforms in gene and cell therapy, viral vectors, vaccination, and beyond, we translate complex concepts into robust, scalable DNA manufacturing solutions. Our comprehensive know-how in plasmid and Minicircle production, strict quality standards, and direct scientific support ensure reliable delivery from high-quality grade to GMP manufacturing.

This is enabled by transparent project workflows and direct access to our scientific experts at every stage, ensuring clarity, speed, and predictable outcomes.

Driven by our passion for nucleic acids and scientific curiosity, we take on ambitious challenges — combining quality, scalability, and reliability to deliver tailored DNA solutions for next-generation therapeutic innovation.

In Focus

GMP at scale: Our state-of-the-art facility delivers GMP Grade plasmid and Minicircle DNA with exceptional purity and consistency for both clinical and commercial applications.

PlasmidFactory is not just another DNA provider.

We are the inventor of the proprietary Minicircle technology — supercoiled, minimalistic, backbone-free DNA enabling safer, more efficient gene delivery for cell engineering, AAV production, vaccine development, and beyond — and the only manufacturer offering it from research to GMP.

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Produce high-purity plasmid and Minicircle DNA across a range of quality grades

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Generate difficult-to-produce and unstable plasmids and Minicircles (e.g. PolyA120, ITRAAV)

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Produce up to 10 g of plasmid material per run with low chromosomal DNA impurities

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Provide plasmid and Minicircle DNA using antibiotic-free fermentation processes

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Guarantee a fixed quantity of material, rather than simply selling a production run

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Provide AAV 2-Plasmid-System for cotransfection

Our quality grades

Scalable plasmid and Minicircle DNA — from research to clinical manufacturing.

PlasmidFactory offers clearly defined quality grades to support every stage of your project — ensuring regulatory alignment, performance consistency, and seamless scale-up within one trusted CDMO.

Scientific Quality (SQ) Grade

Advanced research standard

  • Research Grade – reliable DNA for routine and advanced laboratory applications
  • CCC Grade – ≥95% supercoiled DNA for performance-critical and topology-sensitive workflows

High Quality (HQ) Grade

Highest non-GMP standard

  • EMA guideline-based manufacturing with validated methods and full traceability
  • Ideal for preclinical and early clinical starting material
  • Also available as HQ in GMP: produced in dedicated GMP facility using end-to-end single-use processes

GMP Grade

Clinical & commercial compliance

  • Manufactured in a dedicated EU GMP (Annex 1 & 2) compliant facility
  • End-to-end single-use USP & DSP processes and in-house QP release
  • Various fill & finish options
  • Designed for late-stage clinical trials and commercial supply