POLYARESCUE®

Keeping polyAs intact

POLYARESCUE® technology

PlasmidFactory’s proprietary POLYARESCUE® technology enables the reliable amplification and maintenance of plasmid DNA containing long poly(A) stretches — overcoming one of the key bottlenecks in mRNA template manufacturing.

By combining an optimized fermentation process with advanced Next Generation Sequencing (NGS) analytics, POLYARESCUE® ensures accurate sequencing, precise quantification, and preservation of intact long poly(A) regions — delivering superior DNA templates for efficient and reproducible mRNA production.

  • Stable amplification of long poly(A) stretches (>120 A’s)
    Reliable maintenance of extended poly(A) sequences without instability or truncation.
  • Optimized DNA templates for high-yield, high-quality mRNA manufacturing
    Supports efficient in vitro transcription and consistent mRNA performance.
  • Exceptional product homogeneity and sequence integrity
    Verified poly(A) length and intact plasmid structure through advanced NGS analytics.

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